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3 plasmids (pGL1124, pGL1224 and pGL1217) have been built to enable the substitution of one allele of CYC9, is spread with the tsetse fly and brings about trypanosomiasis in individuals and animals. The two the everyday living cycle and mobile cycle in the parasite are elaborate. Trypanosomes have eleven cdc2-connected kinases (CRKs) and ten cyclin